Which of the following statements most accurately conveys an aspect of cell injury due to impaired calcium homeostasis?

Which of the following statements most accurately conveys an aspect of cell injury due to impaired calcium homeostasis?
Normal intracellular calcium ion levels are higher than extracellular levels.
Ischemia and certain toxins cause a decrease in cytosolic calcium.
Injured cells tend to accumulate calcium.
Low calcium levels cause an activation of damaging enzymes.