Which of the following factors is most responsible for the fact that prefrontal lobotomy is no longer a common treatment for mental illness?

Which of the following factors is most responsible for the fact that prefrontal lobotomy is no longer a common treatment for mental illness? (Points : 0.4)
Individuals treated by lobotomy have difficulty interpreting somatic, visual, and auditory information.
Lobotomy inhibits the individual’s ability to add perception and meaning to sensory information.
Severing connections between the brain and its prefrontal areas inhibits problem solving and results in a loss of ambition.
Loss of communication to and from the prefrontal cortex changes, but ultimately exacerbates, symptoms of mental illness.

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