A health educator is teaching a group of colleagues about the physiology of thermoregulation. Which of the following statements is most accurate?
A. “Prostaglandin E2 (PGE2) exerts a direct fever-producing effect on the hypothalamus.”
B. “Endogenous pyrogens induce host cells to produce exogenous pyrogens.”
C. “PGE2 induces Kupffer cells to initiate a fever response via hepatic sinusoids.”
D. “Arachidonic acid induces cytokines to act on the temperature regulation center.”